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Peptide nucleic acids (PNAs) are artificial nucleic acids with a peptidebackbone instead of sugar phosphate backbone of DNA or RNA. Their resistance todegradation, selectivity and greater binding affinity in comparison to usualnucleic acids led to consideration of their great potential for differentapplications. For example, they can be used in molecular diagnostics andantisense therapeutics such as antimicrobial agents or gene regulatory tools.On the other hand, large hydrophilic property of PNA molecules, which inhibitthem to cross cell membranes readily, is an obstacle for their delivery toconsidered target cells and a limiting criterion for their applications.Therefore, PNA delivery technologies have been developing to hurdle thislimitation. For example, addition of lysine residues, charged membranepenetrating peptide sequences, PNAs conjugated with antibodies or steroids,cationic liposomes as carriers of PNA conjugates, protective peptides andtechnology of photochemical internalization (PCI) as well as by the recenttechnology of nanoparticle-based delivery have been employed. In this articlewe compared different delivery technologies which can be applicable to PNAs. Asa result nanoparticle-based delivery showed more advantages in comparison toothers and its application is growing fast. Keywords: Target cell delivery,Peptide nucleic acid, PNA, Delivery.

Recent applicable delivery approaches of peptide nucleic acids to the target cells