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In recent years, non-invasive neuro-modulation methods such as FocusedUltrasound (FUS) have gained popularity. The aim of this work is to introducethe use of existing open-source technology for surgical navigation to the fieldof multimodal non-invasive brain stimulation. Unlike homegrown and commercialsystems, the use of well-documented, well maintained, and freely availableopen-source components minimizes the learning curve, maximizes technologytransfer outcome, and fosters reproducible science for complex, guidedneuromodulation systems. The described system significantly lowers the entrybar to clinical research and experimentation in the field of non-invasive brainstimulation. Our contribution is two-fold. First, a high-level overview of thecomponents of the descried system is given in this manuscript. Second, allfiles are made available online, with a comprehensive step-by-step manual,quickly allowing researchers to build a custom system. A spatial accuracy of0.93 mm was found through validation using a robotic positioning system.

Open-source neuronavigation for multimodal non-invasive brain stimulation using 3D Slicer