English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Neurodegenerative diseases are characterized as the progressive loss ofneural cells, e.g. neurons, glial cells. Ageing, monogenic variations, viralinfections, and many other factors are determined and speculated as causes forthem. While many individual genes, such as APP for Alzheimer disease and HTTfor Huntington disease, and biological pathways are studied forneurodegenerative diseases, system-wide pathogenesis studies are limited. Inthis study, we carried out a meta-analysis of RNA-Seq studies for threeneurodegenerative diseases, namely Alzheimer's disease, Parkinson's disease andAmyotrophic Lateral Sclerosis (ALS) to minimize the batch effect deriveddifferences and identify the similarly altered factors among studies. Our mainassumption is that these three diseases share some pathological pathwaypattern. For this purpose, we downloaded publicly available Alzheimer's disease(84 patients + 33 controls = 117 individuals), Parkinson's disease (28 patients+ 43 controls = 71 individuals) and ALS (2 studies: 46 patients + 25 control =71 individuals) RNA-Seq data from Sequence Read Archive (SRA) database. Thesignificantly differentially expressed genes common to these studies were firstidentified and analyzed for the patterns in their pathways and variations. Ourmeta-analysis revealed the shared nature of differential gene expression andmutation load of the cellular heat stress response and GABA synthesis inneurodegenerative diseases. The downregulated GABA synthesis-related genes(e.g. GAD1 and GAD2) and the upregulated cellular heat stress response-relatedgenes (e.g. DNAJB6 and HSP90AA1), in addition to their expression patterns,contain unique variations in samples from patients with neurodegenerativediseases. The significance of genes and pathways we identified in this studycorroborated by the recent literature on neurodegenerative diseases.

Meta-analysis of Gene Expression in Neurodegenerative Diseases Reveals Patterns in GABA Synthesis and Heat Stress Pathways