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Understanding the nanoscale structural changes can provide the physical stateof cells/tissues. It has been now shown that increases in nanoscale structuralalterations are associated with the progress of carcinogenesis in most of thecancer cases, including early carcinogenesis. Anti-cancerous therapies areintended for the growth inhibition of cancer cells; however, it is challengingto detect the efficacy of such drugs in early stages of treatment. A uniquemethod to assess the impact of anti-cancerous drugs on cancerous cells/tissuesis to probe the nanoscale structural alterations. In this paper, we study theeffect of different anti-cancerous drugs on ovarian tumorigenic cells, usingtheir nanoscale structural alterations as a biomarker. Transmission electronmicroscopy (TEM) imaging on thin cell sections is performed to obtain theirnanoscale structures. The degree of nanoscale structural alterations oftumorigenic cells and anti-cancerous drug treated tumorigenic cells arequantified by using the recently developed inverse participation ratio (IPR)technique. Results show an increase in the degree of nanoscale fluctuations intumorigenic cells relative to non-tumorigenic cells; then a nearly reverse ofthe degree of fluctuation of tumorigenic cells to that of non-tumorigeniccells, after the anti-cancerous drugs treatment. These results support that theeffect of anti-cancerous drugs in cancer treatment can be quantified by usingthe degree of nanoscale fluctuations of the cells via TEM imaging. Potentialapplications of the technique for cancer treatment are also discussed.

Nanoscale structural alterations in cancer cells to assess anti-cancerous drug effectiveness in cancer treatment using TEM imaging