English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

In the past decade, Genome-Wide Association Studies (GWAS) have delivered anincreasingly broad view of the genetic basis of human phenotypic variation. Oneof the major developments from GWAS is polygenic scores, a genetic predictor ofan individual's genetic predisposition towards a trait constructed from GWAS.The success of GWAS and polygenic scores seems to suggest that we will soon beable to settle debates about whether phenotypic differences among groups aredriven in part by genetics. However, answering these questions is morecomplicated than it seems at first glance and touches on many old issues aboutthe interpretation of human genetic variation. In this perspective piece, Ioutline the ways in which issues of causality, stratification,gene-by-environment interactions, and divergence among groups all complicatethe interpretation of among-population polygenic score differences.

Reading tea leaves? Polygenic scores and differences in traits among groups