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High-energy neutrino astronomy is a key pillar of multi-messenger astronomyand has the potential to also advance fundamental neutrino physics. An accuratesimulation of the neutrino interactions is key in any analysis of neutrinotelescope data. The currently available generator codes of neutrinointeractions use leading order expressions for the differential cross sectionswhich govern rate and kinematics of the events. These calculations are affectedby well-known large theoretical uncertainties, hence the need of beyond leadingorder formalism. Also, a consistent use of modern Parton Density Functions,which are derived using NLO (or NNLO) frameworks, is required. For this reasonand others, the GENIE event generator of neutrino interactions, which is astandard tool in the few-GeV energy regime, has so far been stated to be validup to only about 1 TeV. The work reported here consists of a high-energy (up to10$^{10}$ GeV) extension, which will be available in GENIEv4. It interfacesPYTHIA6 for the hadronization and employs a pragmatic method to assign theflavour of the struck and outgoing quarks, so that the heavy quark production,including bottom and top, is also correctly simulated.

High-energy neutrino event simulation at NLO in Genie for KM3NeT and other observatories