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Interlocus gene conversion (IGC) homogenizes paralogs. Little is knownregarding the mutation events that cause IGC and even less is known about theIGC mutations that experience fixation. To disentangle the rates of fixed IGCmutations from the tract lengths of these fixed mutations, we employ acomposite likelihood procedure. We characterize the procedure with simulations.We apply the procedure to duplicated primate introns and to protein-codingparalogs from both yeast and primates. Our estimates from protein-coding dataconcerning the mean length of fixed IGC tracts were unexpectedly low and areassociated with high degrees of uncertainty. In contrast, our estimates fromthe primate intron data had lengths in the general range expected from IGCmutation studies. While it is challenging to separate the rate at which fixedIGC mutations initiate from the average number of nucleotide positions thatthese IGC events affect, all of our analyses indicate that IGC is responsiblefor a substantial proportion of evolutionary change in duplicated regions. Ourresults suggest that IGC should be considered whenever the evolution ofmultigene families is examined.

A phylogenetic approach disentangles interlocus gene conversion tract length and initiation rate