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One of the most exciting scientific challenges is to detect Earth-likeplanets in the habitable zones of other stars in the galaxy and search forevidence of life.  The ability to observe and characterise dozens of potentially Earth-likeplanets now lies within the realm of possibility due to rapid advances in keyspace and imaging technologies. The associated challenge of directly imagingvery faint planets in orbit around nearby very bright stars is now wellunderstood, with the key instrumentation also being perfected and developed.Such advances will allow us to develop large transformative telescopes,covering a broad UV-optical-IR spectral range, which can carry out the detailedresearch programmes designed to answer the questions we wish to answer:  Carry out high contrast imaging surveys of nearby stars to search for planetswithin their habitable zones. Characterise the planets detected to determinemasses and radii from photometric measurements. Through spectroscopic studiesof their atmospheres and surfaces, search for habitability indicators and forsigns of an environment that has been modified by the presence of life.  Active studies of potential missions have been underway for a number ofyears. The latest of these is the Large UV Optical IR space telescope (LUVOIR),one of four flagship mission studies commissioned by NASA in support of the2020 US Decadal Survey. LUVOIR, if selected, will be of interest to a widescientific community and will be the only telescope capable of searching forand characterizing a sufficient number of exoEarths to provide a meaningfulanswer to the question - Are we alone?.  This paper is a submission to the European Space Agency Voyage 2050 call forwhite papers outlining the case for an ESA contribution to a Large UVOIRtelescope.

The Search for Living Worlds and the Connection to Our Cosmic Origins