English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

In this work a Lattice Boltzmann Immersed Boundary method is used forpredicting the dynamics of rigid and deformable adhesive micro carriers (1 um)navigating a capillary by the size of 10 um with 20% hematocrit. Red cells andparticles are modeled as a collection of mass spring elements responding to abending potential, an elastic potential and total enclosed area conservationconstraint. Furthermore, particle surfaces are uniformly decorated withadhesive molecules (ligands) interacting with receptors disposed on the walls.Particle adhesion is modeled as a short range ligad receptor interaction and interm of formation and destruction probability functions that discriminatewhether a chemical bond can be formed or destroyed. If a bond is established anattractive elastic force is activated. Particle transport and adhesion arecharacterized in terms of their ability to reach the capillary peripheries(margination rate) and firmly adhere the vasculature. This analysis is carriedout systematically by varying particles' and cells' releasing positions andstiffness (Ca = 0 and 10-2). Moreover, three rigid and soft representativeparticles are transported on a finer mesh (Dx = 15 nm) and the chemicalstrength of their adhesive coating is varied (s = 0.5, 1.0, and 2.0) toprecisely analyze the resulting adhesion mechanics. Stiffness is found toweakly influence the margination rate while significantly affect the ability ofsuch constructs to efficiently interact with the endothelium by forming stablechemical bonds.

Vascular journey and adhesion mechanics of micro-sized carriers in narrow capillaries