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Magnetic Particle Imaging (MPI) has been successfully used to visualize thedistribution of superparamagnetic nanoparticles within 3D volumes with highsensitivity in real time. Since the magnetic field topology of MPI scanners iswell suited for applying magnetic forces on particles and micron-sizedferromagnetic devices, MPI has been recently used to navigate micron-sizedparticles and micron-sized swimmers. In this work, we analyze themagnetophoretic mobility and the imaging performance of two different particletypes for Magnetic Particle Imaging/Navigation (MPIN). MPIN constantly switchesbetween imaging and magnetic modes, enabling quasi-simultaneous navigation andimaging of particles. We determine the limiting flow velocity to be 8.18 mL/susing a flow bifurcation experiment, that allows all particles to flow onlythrough one branch of the bifurcation. Furthermore, we have succeeded innavigating the particles through the branch of a bifurcation phantom narrowedby either 60% or 100% stenosis, while imaging their accumulation on thestenosis. The particles in combination with therapeutic substances have a highpotential for targeted drug delivery and could help to reduce the dose andimprove the efficacy of the drug, e.g. for specific tumor therapy and ischemicstroke therapy.

Simultaneous Magnetic Particle Imaging and Navigation of large superparamagnetic nanoparticles in bifurcation flow experiments