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All-dielectric nanophotonics becomes a versatile tool for various opticalapplications, including nanothermometry and optical heating. Its generalconcept includes excitation of Mie resonances in nonplasmonic nanoparticles.However, the potential of resonant dielectric nanoparticles in drug deliveryapplications still have not been fully realized. Here, optically resonantdielectric iron oxide nanoparticles ($\alpha$-Fe$_2$O$_3$ NPs) are employed forremote rupture of microcontainers used as drug delivery platform. It istheoretically and experimentally demonstrated, that $\alpha$-Fe$_2$O$_3$ NPshas several advantages in light-to-heat energy conversion comparing topreviously used materials, such as noble metals and silicon, due to the broaderspectral range of efficient optical heating, and in enhancement of thermallysensitive Raman signal. The $\alpha$-Fe$_2$O$_3$ NPs embedded into the wall ofuniversal drug carriers, polymer capsules, are used to experimentally determinethe local temperature of the capsule rupture upon laser irradiation (170$^o$C).As a proof of principle, we successfully show the delivery and remote releaseof anticancer drug vincristine upon lowered laser irradiation(4.0$\times$10$^4$~W/cm$^2$) using polymer capsules modified with the$\alpha$-Fe$_2$O$_3$ NPs. The biological tests were performed on two primarycell types: (i) carcinoma cells, as an example of malignant tumor, and (ii)human stem cells, as a model of healthy cells. The developed delivery systemconsisting of polymer capsules modified with the dielectric nanoparticlesprovides multifunctional platform for remote drug release and temperaturedetection.

All-optical nanoscale heating and thermometry with resonant dielectric nanoparticles for photoinduced tumor treatment