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One of many important features of the tumour microenvironment is that it is aplace of active Darwinian selection where different tumour clones becomeadapted to the variety of ecological niches that make up the microenvironment.These evolutionary processes turn the microenvironment into a powerful sourceof tumour heterogeneity and contribute to the development of drug resistance incancer. Here, we describe a computational tool to study the ecology of themicroenvironment and report results about the ecology of the tumourmicroenvironment and its evolutionary dynamics.

Fine-grained simulations of the microenvironment of vascularized tumours