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The multidrug resistant Escherichia coli strains causes multiple clinicalinfections and has become a rising problem globally. Themetallo-\b{eta}-lactamases encoding genes are very severe in gram-negativebacteria especially E. coli. This study was aimed to evaluate the prevalence ofMBLs among the clinical isolates of E. coli. A total of 65 E. coli isolateswere collected from various clinical samples of Malaysian patients withbacterial infections. The conventional microbiological test was performed forisolation and identification of E. coli producing MBLs strains in thisvicinity. Multidrug Resistance (MDR) of E. coli isolates were assessed usingdisk diffusion test. Phenotypic methods, as well as genotypic- PCR methods,were performed to detect the presence of metallo-\b{eta}-lactamase resistancegenes (blaIMP, blaVIM) in imipenem resistant strains. Out of 65 E. coliisolates, 42 isolates (57.3%) were MDR. The isolates from urine (19) producedsignificantly more MDR (10) isolates than other sources. Additionally, 19(29.2%) imipenem resistant E. coli isolates contained 10 MBLs gene, 7(36.8%)isolates contained blaIMP and 3(15.7%) isolates contained blaVIM genes. Thisstudy revealed the significant occurrence of MBL producing E. coli isolates inclinical specimens and its association with health risk factors indicating analarming situation in Malaysia. It demands an appropriate concern to avoidfailure of treatments and infection control management.

Detection of Metallo-\b{eta}-Lactamases-Encoding Genes Among Clinical Isolates of Escherichia Coli in a Tertiary Care Hospital, Malaysia