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RADICAL-Cybertools (RCT) are a set of software systems that serve asmiddleware to develop efficient and effective tools for scientific computing.Specifically, RCT enable executing many-task applications at extreme scale andon a variety of computing infrastructures. RCT are building blocks, designed towork as stand-alone systems, integrated among themselves or integrated withthird-party systems. RCT enables innovative science in multiple domains,including but not limited to biophysics, climate science and particle physics,consuming hundreds of millions of core hours. This paper provides an overviewof RCT systems, their impact, and the architectural principles and softwareengineering underlying RCT

RADICAL-Cybertools: Middleware Building Blocks for Scalable Science