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Deciphering the complex interactions between neurotransmission and astrocytic$Ca^{2+}$ elevations is a target promising a comprehensive understanding ofbrain function. While the astrocytic response to excitatory synaptic activityhas been extensively studied, how inhibitory activity results to intracellular$Ca^{2+}$ waves remains elusive. In this study, we developed a compartmentalastrocytic model that exhibits distinct levels of responsiveness to inhibitoryactivity. Our model suggested that the astrocytic coverage of inhibitoryterminals defines the spatial and temporal scale of their $Ca^{2+}$ elevations.Understanding the interplay between the synaptic pathways and the astrocyticresponses will help us identify how astrocytes work independently andcooperatively with neurons, in health and disease.

Computational Astrocyence: Astrocytes encode inhibitory activity into the frequency and spatial extent of their calcium elevations