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This Astro2020 white paper advocates for a multi-messenger approach thatcombines high-energy neutrino and broad multi-wavelength electromagneticobservations to study AGN during the coming decade. The unique capabilities ofthese joint observations promise to solve several long-standing issues in ourunderstanding of AGN as powerful cosmic accelerators.

A Unique Messenger to Probe Active Galactic Nuclei: High-Energy Neutrinos