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Super-resolution ultrasound imaging has been so far achieved in 3-D bymechanically scanning a volume with a linear probe, by co-aligning multiplelinear probes, by using multiplexed 3-D clinical ultrasound systems, or byusing 3-D ultrasound research systems. In this study, a 2-D sparse array wasdesigned with 512 elements according to a density-tapered 2-D spiral layout andoptimized to reduce the sidelobes of the transmitted beam profile. High framerate volumetric imaging with compounded plane waves was performed using twosynchronized ULA-OP 256 systems. Localization-based 3-D super-resolution imagesof two touching sub-wavelength tubes were generated from a 120 secondacquisition.

3-D Super-Resolution Ultrasound (SR-US) Imaging using a 2-D Sparse Array with High Volumetric Imaging Rate