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Mechanisms for non-invasive target drug delivery using microbubbles andultrasound have attracted growing interest. Microbubbles can be loaded with atherapeutic payload and tracked via ultrasound imaging to selectively releasetheir payload at ultrasound-targeted locations. In this study, an ultrasonictrapping method is proposed for simultaneously imaging and controlling thelocation of microbubbles in flow by using acoustic radiation force. Targeteddrug delivery methods are expected to benefit from the use of the ultrasonictrap, since trapping will increase the MB concentration at a desired locationin human body.  The ultrasonic trap was generated by using an ultrasound research system UARPII and a linear array transducer. The trap was designed asymmetrically toproduces a weaker radiation force at the inlet of the trap to furtherfacilitate microbubble entrance. A pulse sequence was generated that can switchbetween a long duration trapping waveform and short duration imaging waveform.High frame rate plane wave imaging was chosen for monitoring trappedmicrobubbles at 1 kHz. The working principle of the ultrasonic trap wasexplained and demonstrated in an ultrasound phantom by injecting SonoVuemicrobubbles flowing at 80 mL/min flow rate in a 3.5 mm diameter vessel.

Simultaneous Acoustic Trapping and Imaging of Microbubbles at Clinically Relevant Flow Rates