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A novel method for the production of important medical radioisotopes has beendeveloped. The approach is based on performing the nuclear reaction in inversekinematics, namely sending a heavy-ion beam of appropriate energy on a lighttarget (e.g. H, d, He) and collecting the isotope of interest. In this work, asa proof-of-concept, we studied the production of the theranostic radionuclide67Cu (T 1/2 =62 h) via the reaction of a 70Zn beam at 15 MeV/nucleon with ahydrogen gas target. The 67Cu radionuclide, alongside other coproducedisotopes, was collected after the gas target on an Al catcher foil and theirradioactivity was measured by off-line {\gamma}-ray analysis. After 36 h fromthe end of the irradiation, apart from the product of interest 67Cu, the mainradioimpurity coming from the 70Zn+p reaction was 69mZn (T 1/2 =13.8 h) thatcan be reduced by further radio-cooling. Moreover, along with the radionuclideof interest produced in inverse kinematics, the production of additionalradioisotopes is possible by making use of the forward-focused neutrons fromthe reaction and letting them interact with a secondary target. A preliminarysuccessful test of this concept was realized in the present study. The mainrequirement to obtain activities appropriate for preclinical studies is thedevelopment of high-intensity heavy-ion primary beams.

A novel approach to medical radioisotope production using inverse kinematics: a successful production test of the theranostic radionuclide 67Cu