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Synthetic DNA can in principle be used for the archival storage of arbitrarydata. Because errors are introduced during DNA synthesis, storage, andsequencing, an error-correcting code (ECC) is necessary for error-free recoveryof the data. Previous work has utilized ECCs that can correct substitutionerrors, but not insertion or deletion errors (indels), instead relying onsequencing depth and multiple alignment to detect and correct indels -- ineffect an inefficient multiple-repetition code. This paper describes an ECC,termed "HEDGES", that corrects simultaneously for substitutions, insertions,and deletions in a single read. Varying code rates allow for correction of upto ~10% nucleotide errors and achieve 50% or better of the estimated Shannonlimit.

An Indel-Resistant Error-Correcting Code for DNA-Based Information Storage