English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

After irradiation of cancer cells in the ion beam therapy method theconcentration of hydrogen peroxide in the cell medium grows significantly. Butthe role of hydrogen peroxide molecules in cancer treatment has not beendetermined yet. We assume that interaction of peroxide molecules with DNAatomic groups can block the genetic information of the cancer cell and lead toits neutralization. To understand the possibility of DNA deactivation in thecell, in the present study the formation of complexes of hydrogen peroxidemolecules with DNA specific recognition sites (nucleic bases) is considered.Using atom-atom potential functions method and quantum-chemical approach, basedon density functional theory, the spatial configurations and energy minima forthe complexes of peroxide and water molecules with nucleic bases are studied.The most probable positions of hydrogen peroxide molecules interacting withnucleic bases are determined, and the possibility of blocking of geneticinformation transfer processes is shown. The obtained data allows us toformulate a new mechanism of the ion irradiation action on living cells, thatcan be useful for cancer treatment.

Blocking of DNA specific recognition sites by hydrogen peroxide molecules in the process of ion beam therapy of cancer cells