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The influence of the daily prolonged administration of silver nanoparticleson cognitive functions of model mammals was studied. The accumulation of silverin whole brain, hippocampus, cerebellum, cortex and residual part of mice brainwas investigated by highly precise and representative Neutron ActivationAnalysis and the histological studies were conducted in the present research.Some of the main results of the comprehensive study are the description of thebiokinetics of silver in the hippocampus, cerebellum and cortex, the finding ofthe jump increase of silver in the hippocampus and cerebellum after the periodof administration of 120 days. Accumulation of silver in the mice brain andhippocampus itself as well as the integrity violation of the CA2 subregioncaused long-term contextual memory impairment at 180 days of silvernanoparticle exposure. However, destruction of CA2 had started 60 days beforethe visible changes in behavior appeared. Complex of the three types of theapproach let us find the cognitive impairment and understand the reasons of it.

Comprehensive study on influence of low dose chronic consumption of  silver nanoparticles on cognitive functions and identification of the effect  reasons