English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Multiple experiments show that various submicron particles such asmagnetosomes, RNA messengers, viruses, and even much smaller nanoparticles suchas globular proteins diffuse anomalously slow in viscoelastic cytosol of livingcells. Hence, their sufficiently fast directional transport by molecular motorssuch as kinesins is crucial for the cell operation. It has been shown recentlythat the traditional flashing Brownian ratchet models of molecular motors arecapable to describe both normal and anomalous transport of such subdiffusingcargos by molecular motors with a very high efficiency. This work elucidatesfurther an important role of mechanochemical coupling in such an anomaloustransport. It shows a natural emergence of a perfect subdiffusive ratchetregime due to allosteric effects, where the random rotations of a "catalyticwheel" at the heart of the motor operation become perfectly synchronized withthe random stepping of a heavily loaded motor, so that only one ATP molecule isconsumed at each motor step along microtubule on average. However, the numberof rotations made by the catalytic engine and the traveling distance both scalesublinearly in time. Nevertheless, this anomalous transport can be very fast inabsolute terms.

Perfect anomalous transport of subdiffusive cargos by molecular motors in viscoelastic cytosol