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Cardiac re-entry regime of self-organised abnormal synchronisation underliedangerous arrhythmias and fatal fibrillation. Recent advances in the theory ofdissipative vortices, experimental studies, and anatomically realistic computersimulations, elucidated the role of cardiac re-entry interaction with fineanatomical features in the heart, and anatomy induced drift. The fact thatanatomy and structural anisotropy of the heart is consistent within a speciessuggested its possible functional effect on spontaneous drift of cardiacre-entry. A comparative study of the anatomy induced drift could be used inorder to predict evolution of atrial arrhythmia, and improve low-voltagedefibrillation protocols and ablation strategies. Here, in micro-CT based modelof rat pulmonary vein wall, and in sheep atria models based on high resolutionserial histological sections, we demonstrate effects of heart geometry andanisotropy on cardiac re-entry anatomy induced drift, its pinning tofluctuations of thickness in the layer. The data sets of sheep atria and ratpulmonary vein wall are incorporated into the BeatBox High PerformanceComputing simulation environment. Re-entry is initiated at prescribed locationsin the spatially homogeneous mono-domain models of cardiac tissue. Excitationis described by FitzHugh-Nagumo kinetics. In the in-silico models, isotropicand anisotropic conduction show specific anatomy effects and the interplaybetween anatomy and anisotropy of the heart. The main objectives are todemonstrate the functional role of the species hearts geometry and anisotropyon cardiac re-entry anatomy induced drift. In case of the rat pulmonary veinwall with ~90 degree transmural fibre rotation, it is shown that the jointeffect of the PV wall geometry and anisotropy turns a plane excitation waveinto a re-entry pinned to a small fluctuation of thickness in the wall.

Dynamics of cardiac re-entry in micro-CT and serial histological sections based models of mammalian hearts