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The search for causative pharmacogenomic loci is being transformed byintegrative omics pipelines, but their outputs have only begun being applied totest design. We assess the direction of the field in light of Biobanks/PheWAS,omics atlases, and AI. We first assess the potential of recent epigenome andspatial genome concepts, datasets, and methods to improve the functionality ofPIP-style pipelines. We then discuss new potential methods of genetic testdesign on the basis of the outputs of such pipelines. We conclude with a visionfor a pharmacophenomic atlas, in which omics atlas data, PheWAS associations,and biobank data would be used with AI to design thousands of genetic tests forclinical deployment in an automated parallel process.

Pharmacogenomics in the Age of GWAS, Omics Atlases, and PheWAS