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Flexible dosing and ease of swallowing are key factors when designing oraldrug delivery systems for paediatric and geriatric populations.Multi-particulate oral dosage forms can offer significant benefits overconventional capsules and tablets. This study proposes the use of an in vitromodel to quantitatively investigate the swallowing dynamics in presence ofmulti-particulates. In vitro results were compared against sensory tests thatconsidered the attributes of ease of swallowing and post-swallow residues.Water and hydrocolloids were considered as suspending vehicles, while thesuspended phase consisted of cellulose pellets of two different average sizes.Both in vivo and in vitro tests reported easier swallow for smallermulti-particulates. Besides, water thin liquids appeared not optimal forcomplete oral clearance of the solids. The sensory study did not highlightsignificant differences between the levels of thickness of the hydrocolloids.Conversely, more discriminant results were obtained from in vitro tests,suggesting that a minimum critical viscosity is necessary to enable a smoothswallow, but increasing too much the carrier concentration affects swallowingnegatively. These results highlight the important interplay of particle sizeand suspending vehicle rheology and the meaningful contribution that in vitromethods can provide to pre-screening multi-particulate oral drug deliverysystems before sensory evaluation.

In vitro and sensory tests to design easy-to-swallow multi-particulate formulations