English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Purpose: A novel dissolution dynamic nuclear polarization (dDNP) polarizerplatform is presented. The polarizer meets a number of key requirements for invitro, pre-clinical and clinical applications. Method: It uses no liquidcryogens, operates in continuous mode, accommodates a wide range of samplesizes up to and including those required for human studies, and is fullyautomated. Results: It offers a wide operational window both in terms ofmagnetic field, up to 10.1 T, and temperature, from room temperature down to1.3 K. The polarizer delivers a 13C liquid state polarization for[1-13C]pyruvate of 70%. The build-up time constant in the solid state isapprox. 1200 s (20 min), allowing a sample throughput of at least one sampleper hour including sample loading and dissolution. Conclusion: We confirm thepreviously reported strong field dependence in the range 3.35 to 6.7 T, but seeno further increase in polarization when increasing the magnetic field strengthto 10.1 T for [1-13C]pyruvate and trityl. Using a custom dry magnet, cold headand recondensing, closed-cycle cooling system, combined with a modular DNPprobe, automation and fluid handling systems; we have designed a unique dDNPsystem with unrivalled flexibility and performance.

Cryogen-Free dissolution Dynamic Nuclear Polarization polarizer operating at 3.35 T, 6.70 T and 10.1 T