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Diffusion-weighted magnetic resonance imaging in brain white matter probestissue microstructure and allows for the estimation of compartmental diffusionparameters. Recently, it became apparent that traditional single-directiondiffusion encodings are not fully sufficient to resolve the white mattercompartmental diffusivities. Multiple diffusion encodings have been suggestedto make the problem less ambiguous, however, it still remained unclear whethersuch protocols would completely solve the problem. Here, we constructivelyprove that a combination of linear and planar diffusion encodings is enough todetermine the parameters of the three compartment white matter model.

A Unique Analytical Solution of the White Matter Standard Model using Linear and Planar Encodings