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The multiscale behavior of the individual fibrin fibers and fibrin clots ismodeled by coupling atomistic simulation data and microscopic experimentaldata. We propose a protofibril element made up of nonlinear spring network,constructed based on the molecular simulation and atomic force microscopyresults to simulate the force extension behavior of fibrin fibers. This newnetwork model also accounts for the complex interaction of protofibrils witheach other, effect of presence of solvent, Coulombic attraction and otherbinding forces. The network model is applied to simulate the force extensionbehavior of single fibrin fiber from atomic force microscopy experiments andshows good agreement. Thus validated fibrin fiber network model is thencombined with a modified version of Arruda-Boyce eight chain model to estimatethe force extension behavior of continuum level fibrin clot, which shows verygood correlation. The results show that this network model is able to predictthe behavior of fibrin fibers as well as fibrin clot at small strains, largestrains and even closer to the break strain. We use the network model toexplain why the fibrin clots and fibers doesn't behave like a worm like chain,instead behaves like a nonlinear spring.

Multiscale Network Model for Fibrin Fibers and Fibrin Clot with Protofibril Binding Mechanics