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We review here some of the historical highlights in exploratory studies ofthe vertebrate embryonic structure known as the neural crest. The study of themolecular properties of the cells that it produces, their migratory capacitiesand plasticity, and the still-growing list of tissues that depend on theirpresence for form and function, continue to enrich our understanding ofcongenital malformations, pediatric cancers but also of evolutionary biology.

The importance and impact of discoveries about neural crest fates