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The thermodynamic aspects of the polymorphic phase transition from{\alpha}-indomethacin to {\gamma}-indomethacin are the fundamental key to findthe most bioavailable phase of indomethacin. In the present work, varying thetemperature and solvent permittivity changes the polymorphic transitions.Hence, the thermodynamic properties such as enthalpy, Gibbs free energy, andentropy of both indomethacin polymorphs are determined in terms of the solventpermittivity as functions of indomethacin's temperature in a vacuum, which arecrucially related to the stability, spontaneity, and reversibility of thepolymorphic transformation.

Theoretical construction of thermodynamic relations for a  solvent-controlled phase transition to improve the bioavailability of drugs:  A case study of indomethacin