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The flow simulation in alveolar region is imperative in understandingtransport of particles and designing aerosol drug delivery systems. Air flow isdependent on alveolar geometry and ventilation conditions. In this work a threedimensional honey-comb like geometry is constructed. A fluid-structure analysisis performed to study normal breathing airflow. Mechanical properties ofalveolar wall tissue play an important role in the deformation of alveoli. Wehave used three distinct material models, linear, non-linear isotropic elasticand viscoelastic, in order to simulate the mechanical behavior of alveolar walltissue and air flow simulation in it. Our simulation shows that linear andnon-linear elastic models cannot describe alveolar tissue behavior as well asviscoelastic.

Fluid-structure interaction analysis of airflow in the lung alveolus