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The main aim of this study is to find the best, most rapid, and the mostaccurate numerical method to find the liquid-gas interface of capillary drivenflow during the time in circular Microchannels by using COMSOL Multiphysicssoftware. Capillary driven flow by eliminating micropumps or any physicalpressure gradient generators can make the microfluidic devices cheaper and moreusable. Hence, by using this two-phase flow, the final costs of lots ofmicrofluidic devices and lab-on-a-chip can significantly be decreased and helpthem to be commercialized. The first step to employing the capillary flow inthese devices is the simulation of this flow inside the microchannels. One ofthe most common and valid software for this work is COMSOL Multiphysics; thisfact reveals the importance of this study. In this research study, simulationresults obtained by using two possible numerical methods in this software, forcapillary flows of water and ethanol in two different circular microchannels,verified and compared with four other methods, which verified experimentallybefore. Finally, the most accurate and time-saving numerical method of thissoftware will be specified. This appropriate technique can contribute tosimulate microfluidic and lab-on-a-chip devices, which are made of differentmechanical and electrical parts, in COMSOL Multiphysics software by choosingthe best method.

Theoretical and Numerical Investigation of Liquid-Gas Interface Location of Capillary Driven Flow During the Time Throughout Circular Microchannels