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We report maximized specific loss power and intrinsic loss power approachingtheoretical limits for AC magnetic field heating of nanoparticles. This isachieved by engineering the effective magnetic anisotropy barrier ofnanoparticles via alloying of hard and soft ferrites. 22 nmCo0.03Mn0.28Fe2.7O4/SiO2 NPs reached a specific loss power value of 3417W/gmetal at a field of 33 kA/m and 380 kHz. Biocompatible Zn0.3Fe2.7O4/SiO2nanoparticles achieved specific loss power of 500 W/gmetal and intrinsic losspower of 26.8 nHm2/kg at field parameters of 7 kA/m and 380 kHz, below theclinical safety limit. Magnetic bone cement achieved heating adequate for bonetumor hyperthermia, incorporating ultralow dosage of just 1 wt% ofnanoparticles. In cellular hyperthermia experiments, these nanoparticlesdemonstrated high cell death rate at low field parameters. Zn0.3Fe2.7O4/SiO2nanoparticles show cell viabilities above 97% at concentrations up to 0.5 mg/mlwithin 48 hrs, suggesting toxicity lower than that of magnetite.

Maximizing Specific Loss Power for Magnetic Hyperthermia by Hard-Soft Mixed Ferrites