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Changes to the axon hillock in frequently firing neurons are known to beimportant predictors of early disease states. Studying this phenomenon iscritical to understanding the first insult implicated in multipleneuro-degenerative disorders. To study these changes we used cyclicalstimulations using micro-electrodes to the axon hillock of mouse intracorticalneurons. Numerical simulation results indicate that axon hillock waterpotential fluctuated sinusoidally on high voltage only. Fluctuations in theamplitude and trend were caused by calcium flow and storage resistance,respectively. The change in axon hillock-stored water was proportional to thechange rate in water potential. Axon hillock diameter increased withfluctuations in calcium free media; moreover, it varied slightly under lowvoltage conditions. Changes in axon hillock diameter were caused by changes inwater potential, which was determined by subcellular gated channels, mediacalcium potential, and other baseline characteristics of neurons.

The effects of cyclical simulation on the axon hillock diameter of murine intracortical neurons