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Let $G$ be a graph and $T$ a certain connected subgraph of $G$. The$T$-structure connectivity $\kappa(G; T)$ (or resp., $T$-substructureconnectivity $\kappa^{s}(G; T)$) of $G$ is the minimum number of a set ofsubgraphs $\mathcal{F}=\{T_{1}, T_{2}, \ldots, T_{m}\}$ (or resp.,$\mathcal{F}=\{T^{'}_{1}, T^{'}_{2}, \ldots, T^{'}_{m}\}$) such that $T_{i}$ isisomorphic to $T$ (or resp., $T^{'}_{i}$ is a connected subgraph of $T$) forevery $1\leq i \leq m$, and $\mathcal{F}$'s removal will disconnect $G$. Thetwisted hypercube $H_{n}$ is a new variant of hypercubes with asymptoticallyoptimal diameter introduced by X.D. Zhu. In this paper, we will determine both$\kappa(H_{n}; T)$ and $\kappa^{s}(H_{n}; T)$ for $T\in\{K_{1,r}, P_{k}\}$,respectively, where $3\leq r\leq 4$ and $1 \leq k \leq n$.

Structure connectivity and substructure connectivity of twisted hypercubes