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There are a number of clinically relevant tasks in digital breasttomosynthesis (DBT) involving the detection and visual assessment of fiber-likestructures such as Cooper's ligaments, blood vessels, and spiculated lesions.Such structures can exhibit orientation dependent variations in conspicuity.This study demonstrates the presence of in-plane orientation-dependent signalconspicuity for fiber-like signals in DBT and shows how reconstructionalgorithm design can mitigate this phenomenon. We uncover a tradeoff betweenminimizing orientation-dependence and preserving depth resolution that isdictated by the regularization strength employed in reconstruction.

Reconstruction Algorithm Design for Mitigating the Orientation Dependent Conspicuity of Fiber-Like signals in Digital Breast Tomosynthesis