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Because human serum transferrin (hTF) exists freely in serum, it is apotential target for cancer treatment drugs and in curing iron-overloadedconditions in patients via long-term transfusion therapy. The understanding ofthe interactions between hTF and metal ions is very important for biological,pharmalogical, toxicological, and other protein engineering purposes. In thispaper, a simple linear free energy correlation is proposed to predict thebinding strength between hTF protein and metal cations. The stability constantsfor a family of metal-hTF complexes can be correlated to the non-solvationenergies and the radii of cations. The binding strength is determined by boththe physical properties (charge and size or ionic radius) and chemicalproperties (non-solvation energy) of a given cation. The binding strengths ofeither divalent and trivalent metals can then be predicted systematically.

An Equation for Predicting Binding Strengths of Metal Cations to Protein of Human Serum Transferrin