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One of the great challenges in biology is to observe, at sufficient detail,the real-time workings of the cell. Many methods exist to do cell measurementsinvasively. For example, mass spectrometry has tremendous mass sensitivity butdestroys the cell. Molecular tagging can reveal exquisite detail using STEDmicroscopy, but is currently neither relevant for a large number of differentmolecules, nor is it applicable to very small molecules. For marker freenon-invasive measurements, only magnetic resonance has sufficient molecularspecificity, but the technique suffers from low sensitivity and resolution. Inthis presentation we will consider the roadmap for achieving in vivometabolomic measurements with more sensitivity and resolution. The roadmap willpoint towards the technological advances that are necessary for magneticresonance microscopy to answer questions relevant to cell biology.

Microscale magnetic resonance detectors: a technology roadmap for in vivo metabolomics