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Standard model of electropration (EP) has long emphasized a single porelifetime to explain post-pulse transport across cell membranes. However, porelifetimes estimated from molecular dynamics (MD) models and and those measuredfrom experimental data differ by several orders of magnitude. We hypothesizethat a broad distribution of lifetimes may describe the post-pulse behavior.Here, we show that pore distribution, number and size of pores, showinteresting behavior in different ranges of pore lifetimes. Interestingly, forlarge electric fields (greater than 1 kV/cm) and short pore lifetimes(approximately 100 ns), an significant loss in pore number occurs during thepulse. Given the large number of EP applications that apply such fields, thisphenomenon may be crucial to post-pulse response of cell membrane to suchfields.

Electroporation dynamics for different pore lifetimes based on the standard model