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Understanding the effect of glassy dynamics on the stability ofbio-macromolecules and investigating the underlying relaxation processesgoverning degradation processes of these macromolecules are of immenseimportance in the context of bio-preservation. In this work we have studied thestability of a model polymer chain in a supercooled glass-forming liquid atdifferent amount of supercooling in order to understand how dynamics ofsupercooled liquids influence the collapse behavior of the polymer. Oursystematic computer simulation studies find that apart from long timerelaxation processes ($\alpha$ relaxation), short time dynamics of thesupercooled liquid, known as $\beta$ relaxation plays an important role incontrolling the stability of the model polymer. This is in agreement with somerecent experimental findings. These observations are in stark contrast with thecommon belief that only long time relaxation processes are the sole player. Wefind convincing evidence that suggest that one might need to review the thevitrification hypothesis which postulates that $\alpha$ relaxations control thedynamics of biomolecules and thus $\alpha$-relaxation time should be consideredfor choosing appropriate bio-preservatives. We hope that our results will leadto understand the primary factors in protein stabilization in the context ofbio-preservation.

Role of $\alpha$ and $\beta$ relaxations in Collapsing Dynamics of a Polymer Chain in Supercooled Glass-forming Liquid