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The most luminous quasars (with bolometric luminosities are 1E47 erg/s) showa high prevalence of CIV {\lambda}1549 and [OIII]{\lambda}{\lambda}4959,5007emission line profiles with strong blueshifts. Blueshifts are interpreted asdue to Doppler effect and selective obscuration, and indicate outflowsoccurring over a wide range of spatial scales. We found evidence in favor ofthe nuclear origin of the outflows diagnosed by [OIII]{\lambda}{\lambda}4959,5007. The ionized gas mass, kinetic power, and mechanical thrust areextremely high, and suggest widespread feedback effects on the host galaxies ofvery luminous quasars, at cosmic epochs between 2 and 6 Gyr from the Big Bang.In this mini-review we summarize results obtained by our group and reported inseveral major papers in the last few years with an eye on challenging aspectsof quantifying feedback effects in large samples of quasars.

Quasar massive ionized outflows traced by CIV {\lambda}1549 and [OIII]{\lambda}{\lambda}4959,5007