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In this work, we review previously developed coarse-grained (CG) particlemodels for biological membrane and red blood cells (RBCs) and discuss theadvantages of the CG particle method over the continuum and atomic simulationson modeling biological phenomena. CG particle models can largely increase thelength scale and time scale of atomic simulations by eliminating fast degreesof freedom while preserving the mesoscopic structures and properties of thesimulated system. One the other hand, CG particle models can be used to capturemicrostructural alternations in diseased RBCs and simulate topological changesof biological membrane and RBCs, which are major challenges to typicalcontinuum representations of membrane and RBCs. The power and versatility ofthe CG particle methods are demonstrated through simulating the dynamicalprocesses involving significant topological changes, such as lipidself-assembly, vesicle fusion and membrane budding.

Modeling Biological Membrane and Red Blood Cells by Coarse- Grained Particle Method