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We derived an ordinary differential equation model to capture the diseasedynamics during blood-stage malaria. The model was directly derived from anearlier age-structured partial differential equation model. The original modelwas simplified due to experimental constraints. Here we calibrated thesimplified model with experimental data using a multiple objective geneticalgorithm. Through the calibration process, we quantified the removal ofhealthy red blood cells and the the preferential infection of reticulocytesduring \textit{Plamodium cynomolgi} infection of \textit{Macaca mulatta}. Thecalibration of our model also revealed the existence of host erythropoieticresponse prior to blood stage infection.

Quantification of Healthy Red Blood Cell Removal and Preferential Invasion of Reticulocytes in Macaca mulatta during Plasmodium cynomolgi Infection