English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Single-bed whole-body positron emission tomography based on resistive platechamber detectors (RPC-PET) has been proposed for human studies, as acomplementary resource to scintillator-based PET scanners. The purpose of thiswork is mainly about providing a reconstruction solution to such whole-bodysingle-bed data collection on an event-by-event basis. We demonstrate a fullythree-dimensional time-of-flight (TOF)-based reconstruction algorithm that iscapable of processing the highly inclined lines of response acquired from asystem with a very large axial field of view, such as those used in RPC-PET.Such algorithm must be sufficiently fast that it will not compromise theclinical workflow of an RPC-PET system. We present simulation results from avoxelized version of the anthropomorphic NCAT phantom, with oncological lesionsintroduced into critical regions within the human body. The list-mode data wasreconstructed with a TOF-weighted maximum-likelihood expectation maximization(MLEM). To accelerate the reconstruction time of the algorithm, amulti-threaded approach supported by graphical processing units (GPUs) wasdeveloped. Additionally, a TOF-assisted data division method is suggested thatallows the data from nine body regions to be reconstructed independently andmuch more rapidly. The application of a TOF-based scatter rejection methodreduces the overall body scatter from 57.1% to 32.9%. The results also showthat a 300-ps FWHM RPC-PET scanner allows for the production of a reconstructedimage in 3.5 minutes following a 7-minute acquisition upon the injection of 2mCi of activity (146 M coincidence events). We present for the first time afull realistic reconstruction of a whole body, long axial coverage, RPC-PETscanner. We demonstrate clinically relevant reconstruction times comparable (orlower) to the patient acquisition times on both multi-threaded CPU and GPU.

Fast full-body reconstruction for a functional human RPC-PET imaging  system using list-mode simulated data and its applicability to radiation  oncology and radiology