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Realistic description of patient-specific mechanical properties of clottingdynamics presents a major challenge. Available patient-specific data fallsshort of robustly characterizing myriads of complex dynamic interactions thathappen during clotting. We propose a simplified switching model for a key partof the coagulation cascade that describes dynamics of just four variables. Themodel correctly predicts prolonged activity of thrombin, an important enzyme inthe clotting process, in certain plasma factor compositions. The activitysustains beyond the time which is conventionally considered to be the end ofclotting. This observation along with the simplified model is hypothesized as anecessary step towards effectively studying patient-specific properties ofclotting dynamics in realistic geometries.

A Novel Simplified Model for Blood Coagulation: A piecewise dynamical model for thrombin with robust predictive capabilities