English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Hippocampal CA3 is crucial for the formation of long-term associative memory.It has a heavily recurrent connectivity, and memories are thought to be storedas memory engrams in the CA3. However, despite its importance for memorystorage and retrieval, spiking network models of the CA3 to date are relativelysmall-scale, and exist as only proof-of-concept models. Specifically, howneurogenesis in the dentate gyrus affects memory encoding and retrieval in theCA3 is not studied in such spiking models. Our work is the first to develop abiologically plausible spiking neural network model of hippocampal memoryencoding and retrieval, with at least an order-of-magnitude more neurons thanprevious models. It is also the first to investigate the effect of neurogenesison CA3 memory encoding and retrieval. Using such a model, we first show that arecently developed plasticity model is crucial for good encoding and retrieval.Next, we show how neural properties related to neurogenesis and neuronal deathenhance storage and retrieval of associative memories in the CA3. Inparticular, we show that without neurogenesis, increasing number of CA3 neuronsare recruited by each new memory stimulus, resulting in a correspondingincrease in inhibition and poor memory retrieval as more memories are encoded.Neurogenesis, on the other hand, maintains the number of CA3 neurons recruitedper stimulus, and enables the retrieval of recent memories, while forgettingthe older ones. Our model suggests that structural plasticity (provided byneurogenesis and apoptosis) is required in the hippocampus for memory encodingand retrieval when the network is overloaded; synaptic plasticity alone doesnot suffice. The above results are obtained from an exhaustive study in thedifferent plasticity models and network parameters.

Neurogenesis and multiple plasticity mechanisms enhance associative memory retrieval in a spiking network model of the hippocampus