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During asymmetric cell division, dynein generates forces, which position thespindle to reflect polarity and ensure correct daughter cell fates. Thetransient cortical localization of dynein raises the question of its targeting.We found that it accumulates at the microtubule plus-ends like in buddingyeast, indirectly hitch-hiking on $\text{EBP-2}^{\text{EB1}}$ likely viadynactin. Importantly, this mechanism, which modestly accounts for corticalforces, does not transport dynein, which displays the same binding/unbindingdynamics as $\text{EBP-2}^{\text{EB1}}$. At the cortex, dynein tracks can beclassified as having either directed or diffusive-like motion. Diffusive-liketracks reveal force-generating dyneins. Their densities are higher on theposterior tip of the embryos, where $\text{GPR-1/2}^{\text{LGN}}$ concentrate,but their durations are symmetric. Since dynein flows to the cortex arenon-polarized, we suggest that this posterior enrichment increases dyneinbinding, thus accounts for the force imbalance reflecting polarity, andsupplements the regulation of mitotic progression via the non-polarizeddetachment rate.

Dynein dynamics at the microtubule plus-ends and cortex during division in the C. $\textit{elegans}$ zygote