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Thrombosis is a common complication following the surgical implantation ofblood contacting devices, and is strongly influenced by the phenomenon ofnear-wall enrichment of platelets. This paper describes a multi-constituentcontinuum approach to study this phenomenon. A mixture-theory model is used todescribe the motion of the plasma and the red blood cells (RBCs) and theinteractions between the two components. A transport model is developed tostudy the influence of the RBC field on the platelets. The model is used tostudy blood flow in a rectangular micro-channel, a sudden expansionmicro-channel, and a channel containing micro crevices (representing apractical problem encountered in most blood-wetted devices). The simulationsshow that in the rectangular channel the concentration of platelets near thewalls is about five times higher than the concentration near the centerline ofthe channel. It is also noticed that in the channel with crevices, extremely alarge number of platelets accumulate in the deep part of the crevices and thismay serve as the nidus for thrombosis occurring in medical devices.  Keywords: Platelets; Blood flow; RBCs; Micro-channel; Mixture theory;Two-fluids; Thrombosis

Transport of platelets induced by red blood cells based on mixture theory