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We present our recent study on baryon-baryon ($BB$) interactions from latticeQCD with almost physical quark masses corresponding to$(m_\pi,m_K)\approx(146,525)$ MeV and large volume $(La)^4=(96a)^4\approx$ (8.1fm)$^4$. In order to perform a comprehensive study of $BB$ interactions basedon lattice QCD calculation with almost physical masses and to make better useof such large scale computer resources, a large number of $BB$ interactionsfrom $NN$ to $\Xi\Xi$ are calculated simultaneously. In this report, we focuson the strangeness $S=-1$ channels of the hyperon interactions by means of HALQCD method. The coupled-channel HAL QCD method is briefly outlined. Thesnapshots of central and tensor potentials in $^1S_0$ and $^3S_1-^3D_1$channels are presented for $\Lambda N$, $\Sigma N$ (both the isospin $I=1/2,3/2$) and their coupled-channel systems.

Lambda-Nucleon and Sigma-Nucleon interactions from lattice QCD with physical masses